R25 VOICE Section 4 - ExEmplar Clinical Machine Learning

Papers discussed in this Section 4 podcast:

  • Anand Avati, Kenneth Jung, Stephanie Harman, Lance Downing, Andrew Ng, Nigam H. Shah. Improving Palliative Care with Deep Learning. arXiv:1711.06402
  • Frizzell JD, Liang L, Schulte PJ, Yancy CW, Heidenreich PA, Hernandez AF, Bhatt DL, Fonarow GC, Laskey WK. Prediction of 30-Day All-Cause Readmissions in Patients Hospitalized for Heart Failure Comparison of Machine Learning and Other Statistical Approaches. JAMA Cardiol. 2017;2(2):204–209. doi:10.1001/jamacardio.2016.3956
  • Joseph Futoma, Sanjay Hariharan, Mark Sendak, Nathan Brajer, Meredith Clement, Armando Bedoya, Cara O'Brien, Katherine Heller. An Improved Multi-Output Gaussian Process RNN with Real-Time Validation for Early Sepsis Detection. arXiv:1708.05894
  • Riccardo Miotto, Li Li, Brian A. Kidd & Joel T. Dudley. Deep Patient: An Unsupervised Representation to Predict the Future of Patients from the Electronic Health Records. Scientific Reports 6, Article number: 26094 (2016) doi:10.1038/srep26094

Podcast Contents:

  • Why These Papers?
  • Predict 30 day all cause readmission
    • How I was surprised.
    • Appreciation for data inputs.
    • Improving the classification
      • Better representation through deep learning.
      • Consider time rather than a snapshot of a given admission.
      • Consider severity of the diseases.
      • Consider medication dosages as a proxy for disease severity.
  • Palliative Care
    • Observation Windows
    • Area under the Precision Recall  Curve.
    • The target is a proxy.
    • Model explanation.
  • Deep patient
    • Building good features.
    • Dealing with noisy data.
    • Sparsity in the number of notes per patient.
    • Sparsity in the number of patients with a feature.
    • Topic Modeling.
    • ICD-9 Granularity.
    • Tools
  • Early Sepsis
    • Undefined time zero.
    • Dealing with time series.
    • irregularly spaced recording.
    • Informed missingness.
    • Case control matching.
    • Matched lookback.
    • Realtime validation.
  • Student Questions